3 points, 95% confidence intervals 1

He had to quit his job. Anna, who’d been a stay at home mom, had to go to work. Their household income is a fraction of what it used to be. Secondary structural outcomes included progression of medial cartilage defects and bone marrow lesions.Results Between group differences did not differ significantly for the primary outcomes of change in overall pain (0.3 points, 95% confidence intervals 1.0 to 0.3) and change in medial tibial cartilage volume (0.4 mm3, 95% confidence interval 15.4 to 14.6), and confidence intervals did not include minimal clinically important differences. None of the changes in secondary outcomes showed differences between groups.Conclusion Lateral wedge insoles worn for 12 months provided no symptomatic or structural benefits compared with flat control insoles. Non drug conservative interventions are considered the first line approach to osteoarthritis management.2 However, given that a substantial proportion of patients with knee osteoarthritis experience progression of structural disease,3 contemporary management also aims to reduce structural deterioration.

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